Anti-Acne Serum
Bioactive Acne Clear Serum
Anti-Acne Serum
Original price was: ฿980.00.฿490.00Current price is: ฿490.00.
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Bioactive Acne Clear Serum, Acne Care for Sensitive Skin
Developed specifically to care for acne-prone skin.
An acne serum that tackles all 4 root causes of acne from the source,
while delivering hydration to prevent dryness and flaking.
Tested by dermatologists and proven by real users,
with visible acne reduction from the first 14 days of use.
Original price was: ฿980.00.฿490.00Current price is: ฿490.00.
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As seen on `Social Media`
TIKTOK
Invested over 600,000 THB in testing and developing Nectapharma’s most advanced acne serum 👨🔬
Yes, a serum that truly helps with acne ✨ Gentle, non-irritating, and dermatologist tested!
TIKTOK
Bioactive Acne Clear Serum — clinically tested on real people 👨🔬
Recommended by those who have struggled with acne. Special thanks to Keenloval for sharing the review 🙏
TIKTOK
Great skin doesn’t come easy — but it doesn’t have to be hard either, with this serum!
TIKTOK
The right ingredients, designed for acne-prone skin.
TIKTOK
Does Bioactive Acne Clear Serum cause purging?! 👀 Watch this clip for the answer!
Why invest over 600,000 THB 💸 just to test one skincare product? 🤔⁉
`Real Results`
with Bioactive Acne Clear Serum
A gentle yet effective acne serum designed for sensitive skin and suitable for all skin types.
It not only helps clear acne but also restores skin smoothness and lasting hydration.
A trusted choice for those seeking an acne solution that is both gentle and truly effective.
Tested under dermatological supervision by Dermscan Asia
on 21 Asian volunteers over 54 days. Results showed:
– 100% of participants experienced a reduction in total acne count within the first 14 days
– 71% experienced reduced skin oiliness
– 100% reported no dryness or peeling, with improved hydration
– 90% reported smoother skin texture
– 95% noticed acne scars appeared visibly reduced
– Acne severity (Global Acne Severity Scale) decreased
– Non-Comedogenic (does not clog pores)
– Non-Acnegenic (does not cause new breakouts)
Bioactive Acne Clear Serum, Complete Acne Defense
This Nectapharma acne serum is specially formulated to directly address acne problems at the root.
It targets all 4 key mechanisms of acne formation and works effectively on all types of acne — including inflammatory acne, clogged pores, and small bumps.
Controls Excess Sebum
Excess oil production is one of the main causes of acne.
This formula helps regulate sebum secretion from sebaceous glands, keeping skin less oily and reducing the risk of pore blockage.
Gentle Exfoliation
While skin naturally renews itself, abnormal shedding can cause buildup of dead cells, leading to clogged pores and acne.
This serum gently stimulates cell turnover, helping remove dead skin cells and reduce recurrence of clogged pores — making it ideal for those seeking an acne serum that is both effective and gentle.
Reduces C. Acnes Bacteria
The overgrowth of C. Acnes bacteria can trigger inflammation and worsen acne.
By reducing bacterial buildup, this serum helps decrease acne severity and prevents future breakouts.
Soothes Inflammation
When acne develops and C. Acnes accumulates, skin enters an inflammatory state — causing redness, swelling, pain, and post-acne marks.
This serum calms irritated skin, helps pimples subside faster, and works effectively as a serum for inflamed acne.
Clinically Supported Active Ingredients
One of the key strengths of SiuSiu Serum – Bioactive Acne Clear Serum is the use of active ingredients at concentrations backed by scientific research, ensuring visible results in treating inflammatory acne, clogged pores, post-acne marks, and skin hydration.
AHA (Alpha Hydroxy Acids) 2%
Gently exfoliates dead skin cells without causing dryness or peeling.
Helps minimize pore blockage and is suitable as a serum for comedonal acne.[1]
Niacinamide 5%
Zinc PCA 1%
Regulates oil production, reduces bacterial buildup, and helps limit the growth of acne-causing bacteria.[10]
`Full Ingredient List` of Bioactive Acne Clear Serum
Water, Niacinamide, Glycereth-26, Camellia Sinensis Leaf Extract, Zinc PCA, Centella Asiatica Extract, Propanediol, Propylene Glycol, Polyacrylate Crosspolymer-11, Garcinia Mangostana Peel Extract, Phenoxyethanol, Pentylene Glycol, 1,2-Hexanediol, Citric Acid, Glycolic Acid, Lactic Acid, Malic Acid, Prunus Armeniaca Fruit Extract, Psidium Guajava Fruit Extract, Vitis Vinifera Fruit Extract, Mangifera Indica Fruit Extract, Prunus Persica Fruit Extract, Rubus Idaeus Fruit Extract, Fragaria Ananassa Fruit Extract, Triethylene Glycol, Dipotassium Glycyrrhizinate, Sodium Hydroxide, Magnolia Officinalis Bark Extract, Paeonia Albiflora Root Extract, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Sorbate, Ehtylhexylglycerin
Alpha-Mangostin 0.67%
Helps reduce inflammation and the growth of acne-causing bacteria, decreasing both comedonal and inflammatory acne without causing irritation.[5, 6]
Green Tea EGCG 1%
Targets acne-related inflammation, regulates excess sebum, and reduces bacterial proliferation.[7]
Centella Asiatica 1%
Soothes acne-related inflammation, calms irritated skin, and replenishes skin hydration.[8, 9]
Hymagic™-4D
A multi-dimensional hydration complex with 4 molecular weights of Hyaluronic Acid, designed to penetrate different skin layers, reduce transepidermal water loss (TEWL), and deeply moisturize.[11]
Apply the acne serum evenly over the entire face, avoiding the eye area.
Start by using every other evening, then gradually increase to twice daily (morning and evening) once the skin adjusts.
For best results, use together with a moisturizer and a sunscreen with at least SPF 30.
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pH 5.44
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Dermatologist tested
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Non-comedogenic (does not clog pores)
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Non-acnegenic (does not cause breakouts)
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Free from fragrance, alcohol, parabens, silicones, mineral oils, and artificial colorants
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Cruelty-free (not tested on animals)
Net Volume: 30 ml.
Frequently Asked Questions
`Bioactive Acne Clear Serum`
A: It helps manage all types of acne, including whiteheads, blackheads, inflammatory acne, hormonal acne, and clogged pores.
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Clogged Pores
Gently reduces pore blockage and promotes proper exfoliation. Works as a comedone-clearing serum without causing irritation. -
Inflammatory Acne
Helps calm inflammation, soothe irritated skin, and reduce redness. Pimples shrink faster and are less likely to leave marks — ideal for those seeking a serum for inflamed acne that both heals and restores. -
Recurring Acne
Targets acne at the root by controlling excess sebum, reducing bacterial buildup, and preventing recurrence. Works as both an oil-control serum and a long-term acne-preventing treatment.
A: The formula is very gentle, so the chance of purging is minimal.
However, purging may occur in some cases due to increased skin cell turnover, which pushes out pre-existing microcomedones beneath the skin. This usually happens within the first 2–6 weeks and often appears in areas where acne previously occurred. Continued use helps the skin adjust and reduces new breakouts over time.
A: Yes. Tested under dermatological supervision by Dermscan Asia, the serum was shown to be non-irritating, non-comedogenic, and non-acnegenic.
A: Yes, it can. Apply the acne spot treatment first, followed by the serum.
If the spot treatment contains Tretinoin (used at night), it is recommended to use the serum in the morning. Once the skin has adjusted, both can be used together, but extra hydration should be maintained depending on individual skin condition.
Real Reviews
`Bioactive Acne Clear Serum`
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nuanpr
01 Jan 1970 | 00:00
The packaging quality is excellent and the size is just right. The serum absorbs easily and felt amazing even from the first use. I gradually adjusted my skin until I could use it both morning and evening.
numneung2527
04 Sep 2025 | 08:15
Fast delivery and everything arrived perfectly. I ordered the BIOACTIVE ACNE CLEAR SERUM — it absorbs quickly. After using it, my pimples started to shrink and the marks faded. I applied it morning and night, and my pimples and small bumps cleared up. The quality is beyond its price, and the promotions are irresistible. 🤣
n*****e
05 May 2025 | 08:00
Really impressed with the quality! From texture, absorption to effectiveness — everything is great. I feel like my acne has reduced a lot, and if I get any, it’s just very small clogged pores. It absorbs beautifully and I have no regrets at all.
References
1
Karwal, K., & Mukovozov, I. (2023). Topical AHA in Dermatology: Formulations, Mechanisms of Action, Efficacy, and Future Perspectives. Cosmetics, 10(5), 131. https://doi.org/10.3390/cosmetics10050131
2
Draelos, Z. D., Matsubara, A., & Smiles, K. (2006). The effect of 2% niacinamide on facial sebum production. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 8(2), 96–101. https://doi.org/10.1080/14764170600717704
3
Khodaeiani, E., Fouladi, R. F., Amirnia, M., Saeidi, M., & Karimi, E. R. (2013). Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. International journal of dermatology, 52(8), 999–1004. https://doi.org/10.1111/ijd.12002
4
Navarrete-Solís, J., Castanedo-Cázares, J. P., Torres-Álvarez, B., Oros-Ovalle, C., Fuentes-Ahumada, C., González, F. J., Martínez-Ramírez, J. D., & Moncada, B. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology research and practice, 2011, 379173. https://doi.org/10.1155/2011/379173
5
Lueangarun, S., Sriviriyakul, K., Tempark, T., Managit, C., & Sithisarn, P. (2019). Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild-to-moderate acne vulgaris: A 12-week, split-face, double-blinded, randomized, controlled trial. Journal of cosmetic dermatology, 18(5), 1395–1403. https://doi.org/10.1111/jocd.12856
6
Krisdaphong, T., & Jedsadapaisid, S. (2012). Antimicrobial activity of Garcinia mangostana extract for anti-acne therapy. IFSCC Magazine, 15(1), 9–12.
7
Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M., & Suh, D. H. (2013). Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. The Journal of investigative dermatology, 133(2), 429–440. https://doi.org/10.1038/jid.2012.292
8
Aszrin, Farashakira & Adam, Siti & Abdul Mutalib, Maisarah & Tang, Hooi & Tang, Shirley. (2024). An overview of Centella asiatica and its therapeutic applications. Life Sciences, Medicine and Biomedicine. 8. 10.28916/lsmb.8.1.2024.146.
9
Shen, X., Guo, M., Yu, H., Liu, D., Lu, Z., & Lu, Y. (2019). Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica. Bioscience, biotechnology, and biochemistry, 83(3), 561–568. https://doi.org/10.1080/09168451.2018.1547627
10
Solabia Group. (n.d.). Zincidone®: Physiological seboregulator. Retrieved from https://www.solabia.com/cosmetics/product/zincidone/
11
Bloomage Biotech. (n.d.). Hymagic™-4D. Retrieved from https://www.bloomagebioactive.com/En/Product/Info/10920
`Nectapharma’s ` philosophy
on product development
Doctors Approved
Pharmacist-formulated with research-backed ingredients, trusted by doctors and public figures.
Research-backed
Every formula is supported by peer-reviewed studies. Real science. No fluff.
Formulated for Synergy
Ingredients that work together, targeting root causes and symptoms in skin, hair, and health.
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