#RetinalSerum
`Trusted by Real Users
Retinal Serum AGELESS DUAL ENCAP 0.1`
`Retinal from Nectapharma
AGELESS DUAL ENCAP 0.1 Retinal Serum,
with results confirmed by real users`
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After 28 days of use, wrinkles were clearly reduced. Suitable for those looking for which retinal serum is best and wanting clinically proven results.
- After continuous use for 56 days:
- 100% of participants showed improved skin smoothness by an average of 48%
- 100% showed improved skin tone evenness by an average of 48%
- 95% showed reduction of forehead wrinkles by an average of 30%
- 95% showed reduction of crow’s feet wrinkles by an average of 29%
- Dermatologist testing also confirmed no irritation.
- The study was conducted under dermatological supervision by Dermscan Asia on 22 Asian volunteers over 56 days.
Key benefits of Retinal serum
Retinal serum is designed for high-performance skin renewal with a lower risk of irritation compared to conventional retinal products. It also helps target senescent “zombie” cells, a key factor in skin aging.
Suitable for those looking for retinal-based anti-wrinkle care and long-term anti-aging skincare to help prevent premature aging.
0.1% Retinal with Dual Encapsulation Technology
Retinal serum combines two forms of encapsulated retinal—Vegan DDS Pure Retinal and Microsponge® 720TRA—into a single formula. It is designed to deliver active ingredients in two skin layers, both deep and surface levels, resulting in high efficacy with improved stability and lower irritation compared to conventional retinal.
It is suitable for those looking for retinal-based skincare to help reduce wrinkles, improve skin smoothness, minimize the appearance of pores, and promote a more even skin tone.
Helps break the cycle of senescent “zombie” cells more effectively.
By combining both Autophagy processes, which help recycle cellular waste and restore the function of damaged skin cells to prevent them from becoming senescent cells, and Senolytic science, which helps target existing senescent cells, it effectively supports healthier skin renewal.
The result is smoother, more elastic, firmer, and more youthful-looking skin.
Low irritation, thoughtfully formulated.
With Dual Encapsulation technology, active ingredients are gradually released into the skin, allowing continuous delivery of retinal over time.
It is further enhanced with SymSitive®, which helps reduce sensations of stinging, itching, and irritation caused by retinal use.
This allows Nectapharma retinal serum to be used consistently for long-term anti-aging results.
Key ingredients of a retinal serum
Retinal serum is developed by carefully selecting synergistic active ingredients that work together effectively, delivering high performance while remaining gentler than conventional retinal serums at the same concentration. It is suitable for continuous use to support long-term youthful-looking skin.
Key ingredients of a retinal serum
Retinal serum is developed by carefully selecting synergistic active ingredients that work together effectively. This results in high performance while being gentler than conventional retinal serums at the same concentration. It is suitable for continuous use to support long-term youthful-looking skin.
5% Vegan DDS Pure Retinal (0.05% Pure Retinal)
Encapsulated Retinal consists of nano-sized particles designed to penetrate deeper into the skin. This allows for more efficient delivery of active ingredients, resulting in enhanced stimulation of collagen and elastin production compared to conventional retinal.
0.25% Microsponge® 720TRA (0.05% Pure Retinal)
Encapsulated Retinal consists of micro-sized particles that are larger in scale and designed to gradually release active ingredients in the upper skin layers. This allows the skin to receive retinal slowly and continuously over time, helping to reduce the risk of irritation.
1% Aquatide 5000BG
Helps slow down skin aging through the autophagy process, which recycles cellular waste and converts it into useful components. This helps restore the function of damaged skin cells and prevents them from becoming senescent (zombie) cells that contribute to skin aging.
It also helps improve skin elasticity, strengthen the skin barrier, and protect against free radicals.
3% Eterwell™ Youth
Targets senescent “zombie” cells that contribute to skin damage and premature aging using Senolytic Science.
It helps boost collagen production, resulting in smoother, more elastic, and firmer-looking skin. Wrinkles appear reduced, and the skin looks more youthful and rejuvenated.
3% SymSitive®
Helps reduce itching, burning, and irritation caused by retinal use, providing a more comfortable skin feel and allowing consistent use of retinal serum over time.
0.1% Melatonin
Antioxidants help repair skin damage, reduce inflammation, and diminish the appearance of wrinkles, resulting in a more youthful-looking complexion.
5% Niacinamide
Helps brighten the skin, fade dark spots, and even out skin tone. It also supports ceramide production to strengthen the skin barrier and helps control excess oil on the face.
`All Ingredients of Retinal Serum`
Water, Niacinamide, Glycerin, Cetyl Ethylhexanoate, Caprylyl Methicone, Polyglyceryl-3 Methylglucose Distearate, Butylene Glycol, Pentylene Glycol, Caprylic/Capric Triglyceride, 4-t-Butylcyclohexanol, Aloe Barbadensis Leaf Juice Powder, C15-19 Alkane, Glyceryl Stearate, Epilobium Fleischeri Leaf/Stem Extract, Phenoxyethanol, PEG-100 Stearate, Phosphatidylcholine, Mannitol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Polyacrylamide, Cellulose, Chlorphenesin, Polyglyceryl-10 Laurate, C13-14 Isoparaffin, Citric Acid, Ammonium Acryloyldimethyltaurate/VP Copolymer, BHT, Bisabolol, Melatonin, Retinal, Squalane, Tocopheryl Acetate, Potassium Hydroxide, Trisodium Ethylenediamine Disuccinate, Tocopherol, Cetyl Alcohol, Laureth-7, Sodium Hyaluronate, Hexacarboxymethyl Dipeptide-12.
Apply all over the face at night, avoiding the eye area.
For the first 2 weeks, use every other night to allow the skin to adapt to retinal. Once the skin has adjusted, gradually increase to nightly use.
It should be used together with a moisturizer, and sunscreen should be applied every morning.
- pH Balanced
- Dermatologist tested
- Fragrance-free, alcohol-free, paraben-free, silicone-free, mineral oil-free, and colorant-free
- Cruelty-free (not tested on animals)
Formulated to minimize irritation through a combination of Dual Encapsulation technology and SymSitive® for enhanced skin comfort and better tolerance compared to conventional retinal products.
30 ml
`Frequently Asked Questions
about Retinal Serum`
A: Retinal works faster and is approximately 10 times more effective than Retinol, leading to quicker visible results in reducing wrinkles and improving skin smoothness. However, it may also have a higher risk of irritation, so it is generally more suitable for those with prior experience using retinoids.
However, Nectapharma has designed the formula to be more user-friendly and gentle by incorporating Dual Encapsulation technology, which controls the release of retinal so the skin receives it gradually and continuously, helping to reduce irritation. It is also enhanced with SymSitive® to help reduce sensations of stinging, itching, and discomfort.
A: It depends on each individual’s skin condition. If you have strong and non-sensitive skin, you can use it.
It is recommended to apply it at night and avoid the eye area. For the first 2 weeks, use it every other day to allow the skin to adapt to retinal. (Recommended layering: moisturizer → retinal → moisturizer).
Once the skin has adjusted, you can increase usage to every night. Always use a moisturizer and apply sunscreen every morning.
A: It is recommended to avoid using Retinal serum at the same time as skincare products with a high risk of irritation, such as strong exfoliating acids (AHA, BHA, PHA), high-strength Vitamin C (Ascorbic Acid), certain acne treatments, or topical medications with potentially irritating effects.
It is advised to use them at different times instead of layering them in the same routine.
A: It can be used with Peptides to help enhance wrinkle reduction while supporting stronger and healthier skin.
However, when used with Retinol, it is recommended to choose only one, as both belong to the retinoid family. Using them together is not advised due to the potential for overlapping effects, which may increase skin irritation.
References
1
Kwon HS, Lee JH, Kim GM, Bae JM. Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin: A randomized double-blind controlled trial. J Cosmet Dermatol. 2018;17(3):471-476. doi:10.1111/jocd.12551
2
Mambwe B, Mellody KT, Kiss O, et al. Cosmetic retinoid use in photoaged skin: A review of the compounds, their use and mechanisms of action. Int J Cosmet Sci. 2025;47(1):45-57. doi:10.1111/ics.13013
3
Health & Beauty Solutions, Inc. Microsponge® N 720TRA: Retinaldehyde Delivery System. Retrieved from: https://www.mineralstech.com/personal-care/personal-care-product-catalog/microsponge-n-720-tra
4
INdermal, Nanovex Biotechnologies. Vegan DDS Pure Retinal: Deep Delivery Nanovesicles with 1% Retinal. Retrieved from: https://indermal.com/vegan-dds-pure-retinal-en/
5
Lim J, Lim CJ, Kim S, et al. Antiaging and antioxidant effects of topical autophagy activator: A randomized, placebo-controlled, double-blinded study. J Cosmet Dermatol. 2019;18(1):197-203. doi:10.1111/jocd.12530
6
Lim CJ, Lee YM, Kang SG, et al. Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. Biomol Ther (Seoul). 2017;25(5):511-518. doi:10.4062/biomolther.2017.119
7
DSM-Firmenich. Eterwell™ Youth: A New Life for Your Skin – Infinite Well-Ageing Powered by Senolytic Science. Retrieved from: https://www.dsm-firmenich.com
8
Srour J, Bengel J, Linden T, et al. Efficacy of a skin care cream with TRPV1 inhibitor 4-t-butylcyclohexanol in the topical therapy of perioral dermatitis. J Cosmet Dermatol. 2020;19(6):1409-1414. doi:10.1111/jocd.13175
9
Symrise AG. SymSitive® 1609: Instant Skin Relief – Skin Tolerance Enhancement & Discomfort Sensation Reduction. Retrieved from: https://www.symrise.com
10
Greco G, Di Lorenzo R, Ricci L, Di Serio T, Vardaro E, Laneri S. Clinical Studies Using Topical Melatonin. Int J Mol Sci. 2024;25(10):5167. Published 2024 May 9. doi:10.3390/ijms25105167
11
Wohlrab J, Kreft D. Niacinamide – mechanisms of action and its topical use in dermatology. Skin Pharmacol Physiol. 2014;27(6):311-315. doi:10.1159/000359974
`Product Philosophy`
Research-Backed
Trademarked Ingredients, Strict Manufacturing Standards, Clinically Proven Results, Safe, Transparent, Trusted by Doctors and Pharmacists.
Thoughtfully Formulated
All of our products are developed by a highly experienced team of pharmacists, and formulated based on multiple scientific studies. Every claim is supported by scientific research.
Trusted Quality
Every formula is carefully developed to ensure that each ingredient works together effectively, providing targeted support while addressing the root causes of the problem.