Many people have heard of Procapil™, but may not know exactly what it is or why it has become such a popular ingredient in modern hair care products. Procapil™ is an advanced hair care active developed to address hair loss at its root cause. It combines three synergistic active ingredients that help reduce DHT, improve blood circulation around the hair follicle, and strengthen hair anchorage, resulting in stronger hair and reduced hair shedding—all supported by scientific research.
| Common Name | Butylene Glycol, Water, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Apigenin, Oleanolic Acid, Biotinoyl Tripeptide-1 |
| Appearance | Pale yellow liquid |
| Source | Natural extracts and synthetic ingredients |
| Benefits | Helps reduce DHT, the primary cause of androgenetic hair loss; improves scalp microcirculation; strengthens hair anchorage; and helps reduce scalp inflammation |
| Recommended Product | Nectapharma Intensive Hair Serum |
TLDR
Procapil™ is a hair-loss active that helps strengthen hair anchorage and reduce hair shedding.
It works by reducing DHT production, improving blood circulation around hair follicles, and reinforcing the attachment of hair follicles to the scalp.
Clinical studies show that 3% Procapil™ used for 4 months increased the Anagen-to-Telogen hair ratio by up to 46%.
What Is Procapil™?
Procapil™ is a proprietary active complex consisting of three key ingredients that work together to restore healthier, stronger hair follicles:
- Oleanolic Acid, derived from the roots of Lovely Hemsleya, inhibits 5α-reductase, the enzyme responsible for converting testosterone into dihydrotestosterone (DHT)—the primary hormonal cause of androgenetic hair loss.
- Apigenin, a naturally occurring flavonoid, helps improve microcirculation around the hair follicle, increasing the delivery of oxygen and nutrients while also helping reduce scalp inflammation.
- Biotinoyl Tripeptide-1 (Biotinyl-GHK) is a matrikine-like peptide that strengthens hair anchorage by stimulating the production of structural proteins such as Collagen IV and Laminin 5, helping hair follicles remain firmly attached to the scalp. [1], [2]
How Does Procapil™ Work?
-
Reduces DHT
Procapil™ inhibits 5α-reductase, preventing the conversion of testosterone into DHT, the hormone primarily responsible for follicle miniaturization and hereditary hair loss. - Improves Blood Circulation
Apigenin promotes vasodilation, increasing blood flow to the scalp and delivering more oxygen and nutrients to the hair follicles.
- Strengthens Hair Anchorage
Biotinoyl Tripeptide-1 stimulates the production of anchoring proteins, including Collagen IV, Laminin 5, Desmoglein, and Desmocollin, helping hair remain more securely attached to the scalp while supporting a longer anagen (growth) phase.
In addition, DNA array studies have shown that Procapil™ increases the expression of genes involved in cellular energy production, cell proliferation, and antioxidant defense, helping protect hair follicles against aging and inflammation. [1]
Clinical Evidence for Procapil™
In a clinical study involving 35 men with more than 20% of their hair in the telogen (shedding) phase, participants applied 3% Procapil™ for 4 months.
The study demonstrated that Procapil™:
- Increased the Anagen-to-Telogen hair ratio by up to 46%.
- Delivered results comparable to 5 months of oral finasteride, while remaining well tolerated and without the systemic side effects associated with oral therapy.
- Improved the structural integrity of hair follicles, with better organization of Collagen IV and Laminin 5, indicating stronger hair anchorage. [1]
After 4 months of using 3% Procapil™, both the hair follicle and the hair bulb became visibly thicker, reflecting healthier and stronger hair follicles. [1]
Hair follicles became thicker after 4 months of using 3% Procapil™.
Hair bulbs became thicker after 4 months of using 3% Procapil™.
