Table Of Contents

Nectapharma’s take

Hesperidin Methyl Chalcone (HMC) is a very interesting antioxidant as it is one of the rare Barrier Repair Antioxidants. It is able to increase Filaggrin and B-glucocerebrosidase which are essential for Ceramide production. The other notable use for HMC is its ability to reduce capillary permeability for dark cicles around the eyes. One major drawback is its super bright color; it is highlighter yellow and can stain anything it touches. Using it at high concentrations can make your skin appear jaundiced.

Common Name Hesperidin Methyl Chalcone
INCI Hesperidin Methyl Chalcone
Source Citrus fruits
Present in Vitamin X
Benefits Antioxidant, Anti-inflammatory, Barrier Repair, Anti-aging

TLDR

Usage rate at 0.05-2%

Antioxidant, Anti-dark Circle, Barrier Repair, Anti-inflammatory

Super duper yellow

Changing temperatures that can create a lot of stress for your skin

With travel comes new environments and changing temperatures that can create a lot of stress for your skin.

Irritated skin, dehydration, breakouts, and clogged pores are just some of the short-term effects you might experience while travelling. Factors like low relative humidity, hot and cold temperatures, and sun exposure are often to blame. Let’s take a closer look.

Relative Humidity
Research shows that low relative humidity can decrease skin hydration. Airplanes are a prime example of a low humidity environment.

Alt text

With travel comes new environments and changing temperatures that can create a lot of stress for your skin.

Irritated skin, dehydration, breakouts, and clogged pores are just some of the short-term effects you might experience while travelling. Factors like low relative humidity, hot and cold temperatures, and sun exposure are often to blame. Let’s take a closer look.

Relative Humidity
Research shows that low relative humidity can decrease skin hydration. Airplanes are a prime example of a low humidity environment.

During a flight, the air outside gets cold while the air inside the plane stays at a comfortable temperature, causing the relative humidity to fall. That’s why your skin can sometimes feel dry or flaky after a flight.

date

26 Jan 2025

categories

Wrinkles

References

1

Huang YB, Lee KF, Huang CT, Tsai YH, Wu PC. (2010). The effect of component of cream for topical delivery of hesperidin. Chem Pham Bull. 58(5): 611-614

2

Hou M, Man M, Man W, Zhu W, Hupe M, Park K, Crumrine D, Elias PM, Man MQ. (2012). Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin. Exp Dermatol. 21(5): 337-340

3

Man G, Mauro TM, Kim PL, Hupe M, Zhai Y, Sun R, Crumrine D, Cheung C, Nuno-Gonzalez A, Elias PM, Man MQ. (2014). Topical hesperidin prevents glucocorticoid-induced abnormalities in epidermal barrier function in murine skin. Exp. Dermatol. 23(9): 645-651

4

Bae JT, Ko HJ, Kim GB, Pyo HB, Lee GS. (2012). Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoaging in human dermal fibroblasts. Phytother Res PTR. 26(12)” 1851-1856

5

Pinho-Ribeiro FA, Hohmann MSN, Borghi SM, et. al. (2015). Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB. Chemico-Biological Interactions. 223: 88-98. doi: 10.1016/j.cbi.2015.01.011

6

Martinez RM, Pinho-Ribeiro FA, Steffen VS, et. al. (2015). Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage. Journal of Photochemistry and Photobiology B: Biology. 148: 145-153. doi: 10.1016/j.jphotobiol.2015.03.030

7

Xiao S, Liu W, Bi J, Liu S, Zhao H, Gong N, Xing D, Gao H, Gong M. (2018). Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair. Journal of Inflammation. 15:14. doi: 10.1186/s12950-018-0190-y